Can you use CBD, Herbs, and Terpenes for anxiety and depression?

The Mayo Clinic defines depression as “…a mental health disorder characterized by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.”

Depression sucks…it can literally suck the life out of a person. The yearly suicide rate in the U.S. is 14 deaths in every 100,000 people.  Major depression has been linked to suicide. The sad news about celebrity suicides shocks the public…but for every publicized suicide there are thousands of private acts of despair that leave families, friends, and communities grieving.

CBD for Depression - Artisan Flower CBD Blog – CBDLightIf you have battled depressive episodes, you are familiar with the cloud of heavy sadness that comes with it. It’s hard to get up. Hard to sleep. Hard to feel joy. Everything takes on a grey, dull, unending sameness and it is hard to see beyond it. Hopeless, helpless. And, unfortunately, traditional anti-depressants such as Lexapro, Prozac, and Celexa come with significant side effects, including addiction and dependence. Patients complain of fatigue, drowsiness, stomach upsets, insomnia, and low sex drive. It is no surprise that there is a so much interest in utilizing natural remedies including CBD for anxiety and depression.

Anxiety, that hideous sense of impending doom and wanting to jump out of your skin, afflicts millions, and yet remains vastly under-treated, with only 36% of those who suffering seeking treatment — and the majority of these are women. And, 50% of more of those people suffering anxiety are ALSO suffering from depression.

Long term, talk therapy, modified lifestyle, changing the circumstances of your life when possible…even getting a pet…may all help to alleviate the symptoms of depression and anxiety. Short term, CBD and herbs may provide you with enough of a “lift” to give you the energy you need to make more sweeping changes. There is sufficient anecdotal and preliminary research based evidence to suggest that combining broad spectrum CBD with particular herbs may help to combat anxiety and depression.

This article covers the following important aspects of how this powerful combination works and what to expect from it:

  • Hemp and Herbs: The Whole is Greater than the Sum of Parts
  • CBD for Anxiety and Depression: What Research Says
  • Terpenes for Anxiety: What Research Says
  • 3 Best Herbs for Anxiety and Depression
  • How Should You Dose CBD?

Hemp and Herbs: The Whole is Greater than the Sum of Parts

The term “entourage effect” was coined by Dr. Robert Mechoulam in 1998. This describes the synergistic effect that results when different compounds in cannabis (whether hemp or marijuana) work together. In short, when different therapeutic compounds are combined, the healing effect that is produced is more powerful and sustained compared to the different compounds working on their own. Broad spectrum hemp refers to hemp that contains a mix of cannabinoids (minus THC) and terpenesand so has  significant entourage effect.

Is it beneficial to combine herbs with CBD?

Even though there are no specific studies that have investigated synergy between CBD and herbs, preliminary research on herbal synergy suggests potential benefits. Herbs that have anti-anxiety and antidepressant effects are likely to enhance the same benefits when combined with broad spectrum CBD.

Cloud Forest Botanicals’ Hemp & Herb bestselling formula, NOVA, is specially formulated with entourage benefits in mind, as it combines turmeric, black pepper, CBD and specific, targeted terpenes. CBD plus ultra-Turmeric. This calming formula targets pain, inflammation and mild anxiety.

CBD for Anxiety and Depression: What Research Says

stress pain anxiety

Stressed? Anxious?

A review that was published in 2014 investigated the anti-anxiety and anti-depressant effects of CBD in animal models. The researchers observed that CBD works through serotonin receptors to exert anti-depressant and anti-anxiety effects. Serotonin helps to regulate a person’s emotional state and well-being.

A subsequent 2015 review showed similar findings with the researchers concluding that CBD does indeed have anti-anxiety effects. The researchers highlighted the need for further clinical studies to confirm these findings.

Many CBD consumers, including our customers, have reported positive benefits after consuming CBD for anxiety and depression, especially when combined with other anxiolytic botanicals.

Terpenes for Anxiety & Depression: What Research Says

Terpenes are the phtyochemicals that give plants their characteristic aromas and tastes. They are present in many, many plants and there are literally thousands of them. In hemp alone, there are over a hundred identified  aromatic compounds—the primary ones being limomeme 1β-caryophyllene, β-myrcene, α-pinene, α-humulene, limonene, and β-pinene. Each of these terpenes, which are found in many different plants besides cannabis,  have verifiable therapeutic potential.

Here in the Cloud Forest, we utilize a wide selection of botanical terpenes in our formulas, depending on the effect we are seeking. Here are a two important terpenes that have anti-anxiety and antidepressant effects:

Beta-caryophyllene: This is a spice-scented terpene that is present in most hemp strains, black pepper, hops, cloves, and rosemary. A 2014 study showed that this terp can reduce anxiety levels in rodent models.

lavender - linaloolLinalool: This terpene has a lavender-like scent and is commonly added to perfumes. A 2010 study  found that it decreases aggressive behavior in mice. Generally, many consumers have reported a feeling of relaxation and enhanced well-being after consuming linalool.

Cloud Forest Botanicals offers two hemp- herbal formulas that are infused with beta-caryophyllene and linalool, among others. ChillOut 1,000 and Sleep Tonight ZZZZ, 500 mg. CBD + 100 mg. CBN.


3 Best Herbs for Anxiety and Depression

Herbs have been used for thousands of years to treat medical conditions, including anxiety and depression. Here are three herbs that you can combine with CBD to enhance anti-anxiety and anti-depressant effects.


Ashwagandha, an adaptogenic herb, is the epitome of herbalism fusing with modern science. Adaptogens are non-toxic plants that work with the body to neutralize stressors and maintain balance, or homeostasis. This herb has shown potential in treating mild and moderate cases of depression. A full-spectrum ashwagandha extract blended with CBD can help with reducing anxiety, promote calm, and balance moods. It is also known as Indian ginseng.

Gotu Kola

Gotu Kola has been widely used in traditional Chinese and Indonesian medicine. One study showed that this herb has anti-anxiety effects in humans. While most studies are preliminary, the herb has shown significant  potential in treating anxiety and depression.

Rosemary (Rosmarinus officianalis)

Rosemary is a common herb found in most parts of the world. It also contains several adaptogenic compounds which are responsible for its therapeutic properties. It has been used as an anti-spasmodic and anti-inflammatory agent. A 2020 study showed that rosemary has potent anti-anxiety effects and helps to boost memory. Compared to traditional medications, rosemary poses less risk for adverse effects.

From the points mentioned above it is clear that combining CBD with herbs and terpenes can help to combat anxiety and depression. That said, how are you going to do this at home and find the proper dose?

How should you dose CBD?

With CBD, there is rarely a one-size-fits-all. Everyone has a unique endocannabinoid system; therefore, each person’s response is individual. Additionally, if you are combining CBD with other beneficial herbs, this becomes even more true. Unlike pharmaceutical drugs with standardized, uniform dosing, CBD is highly individualized, and each person must do a bit of trial and error to find the optimal, minimum dose to obtain the desired effect—the so-called ‘sweet spot.’

CBD Dosage Chart

Always start with the smallest dose suggested and gradually titrate upwards, as needed. Remember to stick to the 3-day rule: maintain the same dose for 3 days before adjusting it. Depending on your body’s response and the severity of your situation, it may take up to two weeks to see gradual improvement. Stay with it, be patient, and remember: Start Low, Go Slow. For more information about dosing, go here.

Most herbs are safe to consume in moderate doses, but you should speak with a health expert before using them to manage anxiety and depression. Fortunately, adverse reactions with herbs are very rare and should they occur, the symptoms are likely to be mild.

And, fortunately, it is not easy to overdose on CBD. If you do overdo it, you might experience some mild diarrhea, fatigue, a slight headache, or changes in appetite. If this happens, stop for 3 days, then resume at half the dose at which you experienced symptoms.

Again, CBD is not a cure for depression or anxiety. But, short term, CBD and herbs may provide you with enough of a “lift” to give you the energy you need to make more sweeping changes and help you back into a more positive, calm and joyful life.

Get Help.

If you or someone you know is suffering from depression and/or anxiety, seek professional help from a qualified medical or mental health professional. It is, quite literally, no laughing matter. People in the midst of major depression or panic/anxiety disorders can’t just ‘shake it off’ or ‘get over it.’
Don’t become–or let someone you love–become a sad statistic. Seek and get help and keep in mind that a multi-pronged approach is often the best way forward.
CBD may be part of this journey towards wellness.

If you need help locating resources, please contact us at

Cloud Forest Botanicals hand crafts unique formulas that marry the Ancient Wisdom of Traditional Herbalism with the Modern Science of Cannabis Medicine. We offer you, our clients, the best of old and new.. You can access them from our online store.

These statements and products have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure or prevent disease. Information presented is for educational purposes only and is not a substitute for or alternative to information from healthcare practitioners. Consult your healthcare professional about potential interactions or complications before using any product. The Federal Food, Drug, and Cosmetic Act requires this notice.